Given two Categories
\usepackage{tikz-cd}
\begin{document}
\begin{tikzcd}
FA \arrow[r,"Ff"] \arrow[d,"\alpha_{A}"]
& FB \arrow[d,"\alpha_{B}"] \\
GA \arrow[r,"Gf"]
& GB
\end{tikzcd}
\end{document}By the definition of Natural Transformation, this is always a Commutative Diagram i.e.